Anti-Inflammatory and Cytotoxic Compounds Isolated from Plants of Euphorbia Genus.

Euphorbia is a large genus of the Euphorbiaceae family. Around 250 species of the Euphorbia genus have been studied chemically and pharmacologically; different compounds have been isolated from these species, especially diterpenes and triterpenes. Several reports show that several species have anti-inflammatory activity, which can be attributed to the presence of diterpenes, such as abietanes, ingenanes, and lathyranes. In addition, it was found that some diterpenes isolated from different Euphorbia species have anti-cancer activity. In this review, we included compounds isolated from species of the Euphorbia genus with anti-inflammatory or cytotoxic effects published from 2018 to September 2023. The databases used for this review were Science Direct, Scopus, PubMed, Springer, and Google Scholar, using the keywords Euphorbia with anti-inflammatory or cytotoxic activity. In this review, 68 studies were collected and analyzed regarding the anti-inflammatory and anti-cancer activities of 264 compounds obtained from 36 species of the Euphorbia genus. The compounds included in this review are terpenes (95%), of which 68% are diterpenes, especially of the types ingenanes, abietanes, and triterpenes (approximately 15%).

Depression symptoms and sweet foods consumption in Mexican college men: the role of emotional eating / Síntomas de depresión y consumo de alimentos dulces en un grupo de varones universitarios mexicanos: el papel de la alimentación emocional

Objective: to evaluate the association between depression symptoms and frequency of unhealthy food consumption, and to explore the mediation effect of emotional eating in this relationship in college men. Method: a cross-sectional study was performed on 764 men at a public university in Mexico City. To assess emotional eating (EE), a validated Spanish-language version of the Eating and Appraisal Due to Emotions and Stress Questionnaire (EADES) was applied. Depression symptoms were evaluated using the scale elaborated by the Center for Epidemiologic Studies (CES-D) and a Questionnaire of Frequency of Food Consumption was used to measure frequency of food consumption. Path and mediation analysis were applied. Results: one-fifth (20.42 %) of college men reported depression symptoms (CES-D ≥ 16). Students with depression symptoms had a higher mean EE score (p < 0.001), a higher frequency of fried food (p = 0.049), sweetened beverages (p = 0.050), and sweet foods consumption (p = 0.005) than students with low CES-D score. According to the mediation analysis, the effect of depression symptoms on the frequency of sweet foods consumption was partially mediated by EE (23.11 % of the total effect). Conclusion: the prevalence of depression symptoms was high. EE is an important mediator in the relationship between depression symptoms and the consumption of sweet foods. Understanding the manifestation of eating behaviors in men and their relationship with depression symptoms may help clinicians and health authorities develop treatment and prevention programs aimed to decrease the risk of obesity and eating disorders.(AU)

Objetivo: evaluar la asociación entre los síntomas de depresión y la frecuencia de consumo de alimentos no saludables y explorar el efecto dela alimentación emocional como variable mediadora en esta relación en hombres universitarios.Método: se realizó un estudio transversal en 764 hombres de una universidad pública en la Ciudad de México. Se aplicó la versión validada enespañol del Eating and Appraisal Due to Emotions and Stress Questionnaire (EADES) para evaluar la alimentación emocional (AE). Los síntomasde depresión fueron evaluados mediante la escala elaborada por el Centro de Estudios Epidemiológicos (CES-D) y el consumo de alimentos seevaluó con el Cuestionario de Frecuencia de Consumo de Alimentos. Se llevó a cabo un análisis de senderos y de mediación.Resultados: una quinta parte (20,42 %) de los hombres universitarios reportaron síntomas de depresión (CES-D ≥ 16). Los estudiantes consíntomas de depresión tuvieron una puntuación media de AE más alta (p < 0,001), mayor frecuencia de consumo de frituras (p = 0,049), debebidas azucaradas (p = 0,050) y de alimentos dulces (p = 0,005) que aquellos con baja puntuación en la escala de CES-D. De acuerdo con elanálisis de mediación, el efecto de los síntomas de depresión sobre la frecuencia de consumo de alimentos dulces fue mediado parcialmentepor la AE (23,11 % del efecto total).Conclusión: la prevalencia de síntomas de depresión fue alta. La alimentación emocional es un mediador importante en la relación entresíntomas de depresión y consumo de alimentos dulces. Conocer la conducta alimentaria en los hombres y su relación con los síntomas dedepresión puede ayudar a los médicos y autoridades de salud a desarrollar tratamientos y programas preventivos destinados a disminuir elriesgo de obesidad y trastornos alimentarios.(AU)

Depression symptoms and sweet foods consumption in Mexican college men: the role of emotional eating.

Introduction: Objective: to evaluate the association between depression symptoms and frequency of unhealthy food consumption, and to explore the mediation effect of emotional eating in this relationship in college men. Method: a cross-sectional study was performed on 764 men at a public university in Mexico City. To assess emotional eating (EE), a validated Spanish-language version of the Eating and Appraisal Due to Emotions and Stress Questionnaire (EADES) was applied. Depression symptoms were evaluated using the scale elaborated by the Center for Epidemiologic Studies (CES-D) and a Questionnaire of Frequency of Food Consumption was used to measure frequency of food consumption. Path and mediation analysis were applied. Results: one-fifth (20.42 %) of college men reported depression symptoms (CES-D ≥ 16). Students with depression symptoms had a higher mean EE score (p < 0.001), a higher frequency of fried food (p = 0.049), sweetened beverages (p = 0.050), and sweet foods consumption (p = 0.005) than students with low CES-D score. According to the mediation analysis, the effect of depression symptoms on the frequency of sweet foods consumption was partially mediated by EE (23.11 % of the total effect). Conclusion: the prevalence of depression symptoms was high. EE is an important mediator in the relationship between depression symptoms and the consumption of sweet foods. Understanding the manifestation of eating behaviors in men and their relationship with depression symptoms may help clinicians and health authorities develop treatment and prevention programs aimed to decrease the risk of obesity and eating disorders.

Introducción: Objetivo: evaluar la asociación entre los síntomas de depresión y la frecuencia de consumo de alimentos no saludables y explorar el efecto de la alimentación emocional como variable mediadora en esta relación en hombres universitarios. Método: se realizó un estudio transversal en 764 hombres de una universidad pública en la Ciudad de México. Se aplicó la versión validada en español del Eating and Appraisal Due to Emotions and Stress Questionnaire (EADES) para evaluar la alimentación emocional (AE). Los síntomas de depresión fueron evaluados mediante la escala elaborada por el Centro de Estudios Epidemiológicos (CES-D) y el consumo de alimentos se evaluó con el Cuestionario de Frecuencia de Consumo de Alimentos. Se llevó a cabo un análisis de senderos y de mediación. Resultados: una quinta parte (20,42 %) de los hombres universitarios reportaron síntomas de depresión (CES-D ≥ 16). Los estudiantes con síntomas de depresión tuvieron una puntuación media de AE más alta (p < 0,001), mayor frecuencia de consumo de frituras (p = 0,049), de bebidas azucaradas (p = 0,050) y de alimentos dulces (p = 0,005) que aquellos con baja puntuación en la escala de CES-D. De acuerdo con el análisis de mediación, el efecto de los síntomas de depresión sobre la frecuencia de consumo de alimentos dulces fue mediado parcialmente por la AE (23,11 % del efecto total). Conclusión: la prevalencia de síntomas de depresión fue alta. La alimentación emocional es un mediador importante en la relación entre síntomas de depresión y consumo de alimentos dulces. Conocer la conducta alimentaria en los hombres y su relación con los síntomas de depresión puede ayudar a los médicos y autoridades de salud a desarrollar tratamientos y programas preventivos destinados a disminuir el riesgo de obesidad y trastornos alimentarios.

Anti-Inflammatory and Cytotoxic Activities of Clerodane-Type Diterpenes.

The secondary metabolites of clerodane diterpenoids have been found in several plant species from various families and in other organisms. In this review, we included articles on clerodanes and neo-clerodanes with cytotoxic or anti-inflammatory activity from 2015 to February 2023. A search was conducted in the following databases: PubMed, Google Scholar and Science Direct, using the keywords clerodanes or neo-clerodanes with cytotoxicity or anti-inflammatory activity. In this work, we present studies on these diterpenes with anti-inflammatory effects from 18 species belonging to 7 families and those with cytotoxic activity from 25 species belonging to 9 families. These plants are mostly from the Lamiaceae, Salicaceae, Menispermaceae and Euphorbiaceae families. In summary, clerodane diterpenes have activity against different cell cancer lines. Specific antiproliferative mechanisms related to the wide range of clerodanes known today have been described, since many of these compounds have been identified, some of which we barely know their properties. It is very possible that there are even more compounds than those described today, in such a way that makes it an open field to discover. Furthermore, some diterpenes presented in this review have already-known therapeutic targets, and therefore, their potential adverse effects can be predicted in some way.

Relationships between dental fluorosis and fluoride concentrations in bottled water and groundwater in low-income children in Mexico.

Introduction: The aim of the current study was to investigate associations between dental fluorosis in children living in low socioeconomic areas in Mexico, and fluoride concentrations in tap water, fluoride concentrations and in bottled water, and body mass index (BMI). Methods: A cross-sectional study involving 585 schoolchildren aged 8-12 years was conducted in communities in a southern state of Mexico with >0.7 parts per million (ppm) fluoride in the groundwater. The Thylstrup and Fejerskov index (TFI) was used to evaluate dental fluorosis, and the World Health Organization growth standards were used to calculate age-adjusted and sex-adjusted BMI Z-scores. A BMI Z-score ≤ -1 SD was used as the cut-off point for thinness, and multiple logistic regression models for dental fluorosis (TFI ≥ 4) were constructed. Results: The mean fluoride concentration in tap water was 1.39 ppm (SD 0.66), and the mean fluoride concentration in bottled water was 0.32 ppm (SD 0.23). Eighty-four children (14.39%) had a BMI Z-score ≤ -1 SD. More than half (56.1%) of the children presented with dental fluorosis in TFI categories ≥ 4. Children living in areas with higher fluoride concentrations in the tap water [odds ratio (OR) 1.57, p = 0.002] and bottled water (OR 3.03, p < .001) were more likely to have dental fluorosis in the severe categories (TFI ≥ 4). BMI Z-score was associated with the probability of dental fluorosis (TFI ≥ 4; OR 2.11, p < 0.001), and the effect size was 29.3%. Discussion: A low BMI Z-score was associated with a higher prevalence of dental fluorosis in the severe category. Awareness of the fluoride concentrations in bottled water may help prevent dental fluorosis, particularly in children exposed to several high fluoride content sources. Children with a low BMI may be more vulnerable to dental fluorosis.

Single Nucleotide Polymorphisms and Dental Fluorosis: A Systematic Review.

Genetic factors contribute to susceptibility and resistance to fluoride exposure. The aim of this systematic review was to identify alleles/genotypes of single nucleotide polymorphisms (SNPs) associated with dental fluorosis (DF) and to identify them as protective or risk factors. PubMed, ScienceDirect, Cochrane Library, Scopus and Web of Science were searched for articles; the last search was performed in August 2022. Human studies that analyzed the relationship between SNPs and DF published in English were included; systematic reviews and meta-analyses were excluded. Methodological quality was graded using the Joanna Briggs Institute checklist and risk of bias was assessed using the Cochrane Collaboration's tool. Eighteen articles were included, 44% of which showed high methodological quality and data from 5,625 participants aged 6 to 75 years were analyzed. The SNPs COL1A2, ESR2, DLX1, DLX2, AMBN, TUFT1, TFIP11, miRNA17, and SOD2 were considered risk factors, and ESR1, MMP20, and ENAM were considered protective factors. In conclusion, there are alleles and genotypes of different single nucleotide polymorphisms involved in increasing or decreasing the risk of developing dental fluorosis.

Association of Age and Temperamental Traits with Children's Behaviour during Dental Treatment.

During paediatric dental treatment, cooperation by children is essential, and temperament can determine their behaviour style. This study aimed to associate temperamental traits and age with behaviour during paediatric dental treatment. This was an observational and cross-sectional study of patients aged 3-10 years. To determine the temperamental traits, an Emotionality Activity and Sociability Temperament Survey (EAS) was performed with the children's parents. The type of behaviour was determined with Frankl's criteria. The total scores for temperamental traits, means, and standard deviations were obtained. The chi-squared test, one-way ANOVA and Student's t-test were applied. A total of 140 patients, who were 5 ± 2.1 years old, participated in the study. Age was determinant for negative behaviour, with a greater frequency in children ≤5 years old (p < 0.05), and a significant negative correlation between age and behaviour (rho = -0.245, p = 0.001). Patients with higher emotionality and activity presented negative and definitely negative behaviours more frequently (p < 0.01). The values for sociability and shyness were similar for positive or negative behaviours. In conclusion, the temperamental traits of emotionality and activity were more frequent in children with disruptive behaviours; therefore, conducting a survey on temperamental traits can be useful for planning behavioural approaches in paediatric dentistry.

Dentists' Perceptions of Their SARS-CoV-2 Risk and Infection Control Needs.

OBJECTIVE: Rapid worldwide dissemination of SARS-CoV-2 has prompted dental professionals to optimise their infection control procedures. To help identify areas of opportunity for protecting dentists and their patients, the aim of this investigation was to analyse Mexican dentists' early perceptions of their risk of exposure to SARS-CoV-2 and their need for comprehensive infection control education. METHODS: This cross-sectional survey was conducted from May 9 to June 3, 2020, during the social distancing phase in Mexico. The survey adhered to relevant guidelines for ethical research design. The questionnaire was designed with Google Surveys and applied online in Spanish. The questionnaire included items on demographics and clinical specialisation. To obtain time-sensitive perceptions, statements were preceded by "While SARS-CoV-2 circulates in the community and new COVID-19 cases are reported"; responses were collected in a 5-point Likert-type scale. RESULTS: The survey's link received 1524 "clicks." Over 25 days, 996 dentists participated (39% men; 89% working in Mexico and 11% in other Spanish-speaking Latin American countries). Most participants (73%) fully agreed that "Looking after patients will pose a risk for the dentist." Total agreement was more common (P = .0001) amongst dentists in Mexico (76%) than amongst those in other countries (53%). Knowing someone with COVID-19 was more common amongst Mexican dentists (P = .0008). The perceived need for enhanced infection control procedures increased with age (P = .0001). Forty-nine percent totally agreed that they sterilise dental handpieces between patients. One-third expressed total agreement that everyone in their clinic was trained in infection control. CONCLUSIONS: Amongst this nonprobabilistic self-selected sample of dentists, age and country of work influenced their perceptions about occupational exposure to SARS-CoV-2 and infection control needs. This survey revealed areas of opportunity to improve infection control education and training for dental professionals.

Body Mass Index and Dental Caries, a Five-Year Follow-Up Study in Mexican Children.

There are conflicting reports on a possible association between body mass index (BMI) and caries. Given the ongoing worldwide increase in obesity, we undertook a 5-year follow-up study on 201 Mexican schoolchildren to analyse their BMI and dental caries experience. The children's weight and height were recorded, and their BMI was calculated using the WHO tables. Decayed, missing, and filled surfaces in both dentitions (dmf/DMFS) were assessed annually according to WHO criteria by two calibrated researchers (Kappa value 0.92 p < 0.001). The means, standard deviation, an ANOVA, and Student's t-test were calculated to analyse the relationship between the variables. At baseline, the children had an average of 6.5 ± 0.5 years, a BMI of 17.2 ± 3.1 (CI95% 16.8-17.6). Their weight's classifications were 61% normal, 19% obese, 17% overweight, and 3% showed thinness. At the end of the study, their BMI were 20.6 ± 4.4 (CI95% 19.8-21.5), 53% normal, 15% obese, 30% overweight, and 2% thin. The children's dmfs decreased from 5.8 ± 9.2 to 1.8 ± 3.4 and the DMFS increased from 0.07 ± 05 to 1.4 ± 2.3. In this population based on a 5-year follow-up, caries prevalence and incidence were not significantly associated with the BMI. However, schoolchildren with malnutrition had the highest caries indexes.

Recent Biomarkers for Monitoring the Systemic Fluoride Levels in Exposed Populations: A Systematic Review.

Fluorides are compounds that can be found in the minerals of soil with volcanic rocks. Different populations are exposed to high levels of fluorides through drinking water that, due to their chronic intake, cause several types of damage to health. Nails and hair, denominated as recent biomarkers, have been employed for monitoring systemic fluoride from long-term exposure to fluorides. The aim of this study was to perform a systematic review of the use of recent biomarkers for monitoring systemic fluoride levels in exposed populations and verify their validity in the measurement of the fluorine (F-) concentration within the body. A digital search was performed in the databases PubMed/Medline, Springer Link, Cochrane, and Scopus of original articles that employed recent biomarkers for monitoring systemic F-. Seventeen articles were included in this analysis; the recorded variables were the F- amount in each assessed biomarker, source of exposure, and total daily fluoride intake (TDFI). TDFI was associated with F- in nails and hair, as well as the exposure through drinking water. In conclusion, recent biomarkers are adequate for monitoring the systemic fluoride levels by evaluating the chronic/subchronic exposure through different sources, mainly drinking water, considering nails better than hair for this purpose.

ENAM Gene Variation in Students Exposed to Different Fluoride Concentrations.

The ENAM gene is important in the formation of tooth enamel; an alteration can affect the lengthening of the crystals, and the thickness in enamel. The objective was to determine the presence of the single nucleotide variant (SNV) rs12640848 of the ENAM gene in students exposed to different concentrations of fluoride. METHODS: A cross-sectional study was conducted on students exposed to high concentrations of fluoride in the city of Durango which were divided according to the severity of fluorosis and dental caries. Genotype determination was performed by DNA sequencing. The relationship between the severity of dental fluorosis and the allele distribution was determined by the Fisher's exact and Kruskal-Wallis tests. RESULTS: Seventy-one students were included for the sequencing. In the different allelic variations, for the normal genotype AA/TT, the control group presented 75%, for the AG/TC variation, 70.8% in the TF ≤ 4 group, 65% in TF ≥ 5, and 16.7% in TF = 0; with respect to GG/CC variation, 12.5% in TF ≤ 4, 22% in TF ≥ 5, and 8.3% in TF = 0 group (p = 0.000). CONCLUSION: The ENAM gene showed an association in the population exposed to different concentrations of fluoride.

Ecological study on needs and cost of treatment for dental caries in schoolchildren aged 6, 12, and 15 years: Data from a national survey in Mexico.

To determine the treatment needs and the care index for dental caries in the primary dentition and permanent dentition of schoolchildren and to quantify the cost of care that would represent the treatment of dental caries in Mexico.A secondary analysis of data from the First National Caries Survey was conducted, which was a cross-sectional study conducted in the 32 states of Mexico. Based on dmft (average number of decayed, extracted, and filled teeth in the primary dentition) and DMFT (average number of decayed, extracted, and filled teeth in permanent dentition) information, a treatment needs index (TNI) and a caries care index (CI) were calculated.At age 6, the TNI for the primary dentition ranged from 81.7% to 99.5% and the CI ranged from 0.5% to 17.6%. In the permanent dentition, the TNI ranged from 58.8% to 100%, and the CI ranged from 0.0% to 41.2%. At age 12, the TNI ranged from 55.4% to 93.4%, and the CI ranged from 6.5% to 43.4%. At age 15, the TNI ranged from 50.4% to 98.4%, and the CI ranged from 1.4% to 48.3%. The total cost of treatment at 6 years of age was estimated to range from a purchasing power parity (PPP) of USD $49.1 to 287.7 million in the primary dentition, and from a PPP of USD $3.7 to 24 million in the permanent dentition. For the treatment of the permanent dentition of 12-year-olds, the PPP ranged from USD $13.3 to 85.4 million. The estimated cost of treatment of the permanent dentition of the 15-year-olds ranged from a PPP of USD $10.9 to 70.3 million. The total estimated cost of caries treatment ranged from a PPP of USD $77.1 to 499.6 million, depending on the type of treatment and provider (public or private).High percentages of TNI for dental caries and low CI values were observed. The estimated costs associated with the treatment for caries have an impact because they represent a considerable percentage of the total health expenditure in Mexico.

Evaluating the changes in molar incisor hypomineralization prevalence: A comparison of two cross-sectional studies in two elementary schools in Mexico City between 2008 and 2017.

BACKGROUND: Little information is available on the trends over time of the prevalence of molar incisor hypomineralization (MIH). This condition may be preventing dental caries decline. AIM: (a) To compare the prevalence of MIH, in Mexico City schoolchildren, evaluated in 2008 with a group evaluated in 2017, (b) to identify the association of MIH with dental caries, and (c) to assess the mother's perception of her child's oral health status. DESIGN: Two cross-sectional studies performed in 2008 and in 2017 were compared. The oral examiner and the selected schools were the same in both surveys. RESULTS: A total of 549 schoolchildren were evaluated. The prevalence of MIH in the first survey was 20.3%, and 31.9 % in the second survey, (p = .002). Children with MIH were more likely to have dental caries. The odds ratio was 2.24 (p = .036) and 4.18 (p ˂ .001) in the first and second surveys, respectively. Mothers of children with MIH perceived worse oral health status of their children than the mothers whose children did not have MIH (odds ratio = 4.47, p ˂ .001). CONCLUSION: The findings portray a clear increase in prevalence of MIH and highlight the need for increased awareness about this condition among dentists and the general population.

Dentists Survey on Adverse Events During Their Clinical Training.

BACKGROUND: Adverse events (AEs) begin challenging the safe practice of dentistry early when students start treating patients at dental school. We assessed the frequency with which dentists caused common AEs during their undergraduate clinical training. METHODS: A convenience sample of dentists, graduated from more than 34 dental schools in Mexico and other Spanish speaking countries, answered a confidential, self-administered questionnaire with closed-format questions on common AEs they caused and their active errors that could have led to AEs in the teaching clinics. RESULTS: Of 207 participants, 80% had graduated recently. As undergraduates, 79% caused AEs; 38% admitted to causing one adverse event, 41% to causing two or more, and 36% committed active errors that could have hurt patients. No significant associations between AEs and sex or type of school were observed. CONCLUSIONS: The results indicate that dental students caused AEs or committed errors that placed patients at risk, during their clinical training. PRACTICAL IMPLICATIONS: Dental schools must identify challenges to patient safety at their teaching clinics and introduce risk reduction strategies to protect their patients and foster a safety culture in dental education.

DNA sequencing reveals AMELX, ODAM and MMP20 variations in dental fluorosis.

OBJECTIVE: Dental fluorosis (DF) is a dental development disorder caused by chronic fluoride overconsumption. There are differences in the susceptibility to and severity of DF in studied populations. The objective of the present study was to determine if single-nucleotide variations (SNVs) in the genes Amelogenin (AMELX), Odontogenic Ameloblast Associated (ODAM) and Matrix Metalloproteinase 20 (MMP20) are associated with DF by evaluating the relationship between variations in these genes and the degree of DF severity. SUBJECTS AND METHODS: Schoolchildren from two regions of Durango State and Mexico City, Mexico, were studied. The DF phenotype was determined using the Thylstrup and Fejerskov (TF) index. DNA was obtained from the buccal mucosa of each participant, and the presence of the variations rs946252 in AMELX, rs1514392 in ODAM and rs1784418 in MMP20 was determined by bidirectional DNA sequencing. RESULTS: A total of 180 DNA samples from 30 schoolchildren from 2 areas of Durango State were sequenced and analyzed. Differences in the severity of DF were found between the study areas (p = 0.006). SNVs in theMMP20 gene were present in 76.9 % of the participants in the high fluoride concentration and lower DF severity area. CONCLUSION: AMELX and ODAM variations was not different between the two populations with respect to DF severity; however, the presence of rs1784418 differed between phenotypes with regard to susceptibility to DF. Therefore, MMP20 might be related to the various phenotypes of DF and may serve as a protective marker.

Prevalence and Severity of Molar-Incisor Hypomineralization, Maternal Education, and Dental Caries: A Cross-Sectional Study of Mexican Schoolchildren with Low Socioeconomic Status.

OBJECTIVES: The aims of this study were to identify the prevalence of molar-incisor hypomineralization (MIH) in a group of low-income schoolchildren and to evaluate the role of maternal education on MIH and dental caries in these children. MATERIALS AND METHODS: This cross-sectional study enrolled 686 schoolchildren. To evaluate dental caries, the International Caries Dental Assessment System II (ICDAS) criteria were utilized. MIH was assessed by using the European Academy of Paediatric Dentistry criteria. Mixed-effects models were applied for the data analysis. RESULTS: The prevalence of MIH was 35.4% (244). Most children exhibited moderate MIH (163, 67.1%), followed by mild MIH (45, 18.5%) and severe MIH (35, 14.4%). Caries presence in the first permanent molars, evaluated using ICDAS score, indicated that the mean number of noncavitated and cavitated lesions (ICDAS ≥2) was 0.90 (±0.30); the mean number of lesions with ICDAS ≥3 was 0.36 (±0.48). Odds ratio (OR) analysis of MIH severity revealed that the children of mothers with low education were more likely to exhibit MIH (OR 2.13; 95% confidence interval [CI]: 1.25-3.85). Modeling of dental caries (ICDAS ≥3) revealed that low maternal education (OR 2.27; 95% CI: 1.25-4.16) and the presence of MIH (OR 4.37; 95% CI: 3.05-6.25) were associated with dental caries. CONCLUSIONS: There were associations between low maternal education and both MIH and dental caries. The presence of both initial and cavitated caries lesions was associated with MIH. Dentists should offer adequate advice to mothers with children with MIH, based on their educational background.

Fissure Depth and Caries Incidence in First Permanent Molars: A Five-Year Follow-Up Study in Schoolchildren.

This study aimed to evaluate the association between the fissure depth (tooth morphology) of permanent molars and dental caries incidence with a five-year follow-up period. In total, 110 Mexican schoolchildren aged seven years were recruited at baseline, of which 88 children completed the follow-up assessments. The fissure depths of the first permanent lower molars were recorded, and dental caries [decayed, missing, and filled deciduous surfaces (dmfs) and decayed, missing, and filled permanent surfaces (DMFS)] was evaluated annually. A generalized estimating equation model was constructed for evaluating the association between dental caries and fissure depth. The initial and final DMFS scores were 0.02 (±0.2) and 1.55 (±2.49), respectively. The generalized estimating equation model showed that children with deep molar fissures were more likely to develop caries lesions, (Odds Ratio OR = 3.15, p = 0.028) compared to children with shallow fissures. Moreover, dental caries in primary teeth (OR = 1.07, p = 0.005) was associated with the development of carious lesions in the permanent dentition. Fissure depth was a useful predictor of dental caries, according to this five-year follow-up study. The detection of deep occlusal fissures in the lower first permanent molars could contribute to the identification of children at high risk of dental caries. Tooth morphology may be used to identify children at a higher caries risk, particularly in settings with limited resources.

Riesgo a caries: diagnóstico y sugerencias de tratamiento / Caries risk: diagnosis and treatment suggestions

El objetivo de este trabajo fue analizar el estado de la ciencia sobre factores de riesgo a caries, con la fi nalidad de brindar elementos de juicio al odontólogo para que conozca cómo identifi car el riesgo de enfermar de sus pacientes y pueda generar las estrategias de tratamiento y número de citas al año recomendadas para su seguimiento. En este análisis se describen algunos conceptos básicos sobre caries, se introduce al lector en el diagnóstico por riesgos y se dan pautas generales para el tratamiento y seguimiento del paciente (AU)

The purpose of this work was to analyze the state of the science on caries risk assessment, in order to provide elements of judgment to the dentist so that he knows how to identify the risk to get sick of his patients and can generate treatment strategies and number of appointments per year recommended for follow-up. In this analysis, some basic concepts about caries are described, the reader is introduced to risk diagnosis and general guidelines are given for the treatment and follow-up of the patient (AU)

Proceso de erupción de los primeros molares permanentes / Eruption of the first permanent molars

Introducción: el proceso de erupción de la dentición permanente puede alterarse por causas sistémicas y/o locales, debido a que su periodo es largo. Objetivo: identificar la edad inicial de erupción de primeros molares permanentes y el momento de su oclusión en escolares al sur de la ciudad de México. Métodos: estudio longitudinal, descriptivo realizado en la escuela de educación básica Espartaco al sur de la ciudad de México. La muestra quedó conformada por 53 escolares (31 niñas / 22 niños) cuyos padres firmaron el consentimiento informado. Las variables estudiadas fueron sexo, edad cronológica y erupción de primeros molares permanentes. La muestra fue revisada cuatrimestralmente por dos examinadores calibrados, bajo buena iluminación y con espejo dental. En la identificación de erupción se usaron los criterios: no erupcionado, erupción inicial y oclusión funcional. Se realizaron revisiones posteriores hasta observar todos los molares ocluidos. Se calcularon medidas de tendencia central y dispersión por edad cronológica (inicio y oclusión funcional), así como el promedio que duró el proceso de erupción. Los datos fueron analizados con el paquete SPSS (versión 21). Resultados: la edad de erupción inicial de los primeros molares permanentes superiores derechos fue de 6,69 años, izquierdos de 6,68, inferiores derechos 6,67 años e izquierdos de 6,59. El primer molar que ocluyó fue el superior derecho (7,29 años) y los últimos ambos molares inferiores (7,56 años). La duración global promedio para llegar a oclusión del molar superior derecho fue 0,6 años, para el izquierdo 0,7 años, para el molar inferior derecho 1,1 años y para el izquierdo 1 año. Conclusiones: en la población estudiada la edad promedio del inicio de la erupción del primer molar permanente es a los 6,6 años. En los niños los primeros molares inferiores son los que inician la erupción y los últimos en llegar a oclusión(AU)

Introduction: due to its long duration, the process of eruption of permanent dentition may be affected by a number of systemic and/or local factors. Objective: identify the initial age for the eruption of the first permanent molars and the moment of their occlusion among students from a school located south of Mexico City. Methods: a longitudinal descriptive study was conducted at Espartaco elementary school south of Mexico City. The study sample consisted of 53 students (31 girls / 22 boys) whose parents granted their informed consent. The variables studied were sex, chronological age and eruption of the first permanent molars. The sample was checked every three months by two qualified examiners in a well-lit place using dental mirrors. The following criteria were applied: unerupted, initial eruption and functional occlusion. Further examination was performed to include all occluded molars. Estimation was made of central tendency and dispersion measures by chronological age (initial eruption and functional occlusion), as well as the average duration of the eruption process. Data were processed with the statistical software SPSS version 21. Results: initial eruption age was the following: 6.69 years for the first permanent upper right molars, 6.68 for the upper left, 6.67 for the lower right, and 6.59 for the lower left. The first molar to occlude was the upper right (7.29 years) and the last ones were the two lower molars (7.56). Overall average time to reach occlusion was 0.6 year for the upper right molar, 0.7 for the upper left, 1.1 for the lower right and 1 year for the lower left. Conclusions: in the population studied average age for the start of eruption of the first permanent molar was 6.6 years. Among boys the first lower molars are the ones that start eruption and the last to reach occlusion(AU)

Impact of Dental Fluorosis, Socioeconomic Status and Self-Perception in Adolescents Exposed to a High Level of Fluoride in Water.

Objective: To identify adolescents' self-perception of dental fluorosis from two areas with different socioeconomic levels. Methods: A cross-sectional, descriptive study was conducted with 15-year-old youths by applying a questionnaire designed and validated to assess self-perceptions of dental fluorosis in two areas with different socioeconomic statuses (SESs). Fluorosis was clinically evaluated by applying the Thylstrup and Fejerkov (TF) index on the upper front teeth. Results: A total of 308 adolescents were included in the study. The medium-SES population, which was exposed to 2.5 ppm of fluoride in water, and the low-SES population, which was exposed to 5.1 ppm, presented the following levels of dental fluorosis: TF 2-3 (50%), TF 4-5 (45.6%) and TF 6-7 (4.4%) for medium SES and TF 2-3 (12.3%), TF 4-5 (67.1%) and TF 67 (20.6%) for low SES. A significant association was found between self-perception and dental fluorosis in those with medium and low SESs (p < 0.05). The multiple regression model found differences between TF levels and self-perception, with a 6-7 TF level for concerns about color (OR = 1.6), smile (OR = 1.2) and appearance (OR = 3.36). Conclusions: Self-perceptions of dental fluorosis affect adolescents such that adolescents with a medium SES have more negative perceptions than those with a low SES. Such perceptions increase as the TF index increases.